Like all blood cells, monocytes develop from pluripotential stem cells. The first committed cell along the monocyte development tract is the monoblast, a cell type virtually identical in morphology to the myeloblast of the granulocytic series. Monoblasts develop into promonocyte, a large cell with a slightly indented nucleus. Promonocytes develop into mature monocytes.
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| Stem Cell | monoblast | Promonocyte |
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