Tulane Cancer Center Selected Representative Publications

AIDS-related cancers Bone marrow Breast cancer Gastro-intestinal cancer Genetics & gene therapy Genito-urinary cancer Gynecological & obstetric

Hodgkin's disease Kidney (renal) cancer Liver (hepatocellular) cancer Leukemia Lung & esophageal cancer Lymphoma

Myeloma Ophthalmic cancer Ovarian & cervical cancers Prostate cancer Wilms' tumor

See also: Selected publications from the Hematology-Oncology labs

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This list is a representative sampling of the projects and publications of the cancer researchers at Tulane. Only a small fraction of our cancer research is cited here. To further inquire about cancer research or treatment programs at Tulane, please call one of these toll-free numbers:
1 (800) 588-5300 (Physicians) 24 hours a day
1 (800) 588-5800 (Patients and others) 8:00 am to 8:00 pm US Central Time


AIDS-related cancers

• Beilke MA, Greenspan DL, Impey A, Thompson J, Didier PJ. Laboratory study of HIV- 1 and HTLV-I/II coinfection. J Med Virol 44:132-43 (1994)
• Mondal D, Agrawal KC. Effect of HIV type 1 Tat protein on butyric acid-induced differentiation in a hematopoietic progenitor cell line. AIDS Res Hum Retroviruses 12(16): 1529-36 (1996)
• Swanton RG, Kuske RR, Hawkins GB, Golodner EH, Bell K, Fidler RY, Zakris EL. Diagnosis and treatment of disseminated epidemic Kaposi's Sarcoma with radiation therapy and chemotherapy: A case study. South Med J 89: 718-722 (1996)
• Bessinger R, Beilke MA, Kissinger P, Jarrott C, Tabak O. Retroviral coinfections at a New Orleans HIV outpatient clinic. J AIDS Human Retrovirology 14:67-71 (1997)
• Beilke MA, Japa S, Vinson D. HTLV-I and HTLV-II virus expression increase with HIV-1 co-infection. J AIDS Human Retrovirology 17:391-97 (1998)
• Habis A, Baskin GB, Murphey-Corb M, Levy LS. Simian AIDS-associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin's lymphoma. AIDS Res Human Retroviruses 15: 1389-1398 (1999)
• Habis A, Baskin GB, Simpson L, Fortgang I, Murphey-Corb M, Levy LS. Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. AIDS Res Human Retroviruses 16: 163-171 (2000)
• Santiago K, Rivera A, Cabanis D, Dhurandhar N, Moroz K. FNA of CMV Sialadenitis in a patient with Acquired Immunodeficiency Syndrome: Pitfalls of Diff-Quik staining. Diagn Cytopathol 22: 101-103 (2000)
• Fortgang I, Rege T, Baskin GB, Murphey-Corb M, Levy LS. Variation in simian immunodeficiency virus env V1 region in SAIDS-associated lymphoma. AIDS Res Human Retroviruses 17:459-465 (2001)

See also:

• The Garry Lab: HIV Cytopathology
• AIDS-related cancer clinical trials

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Bone Marrow Transplant

• Mudad R, Vredenburgh J, Paulson EK, Ross M, Meisen berg B, Hussein A, Peters WP. A radiologic syndrome after high dose chemotherapy and autologous bone marrow transplantation, with clinical and pathologic features of systemic candidiasis. Cancer 74:1360-1366 (1994)
• Mudad R, Hussein A, Peters WP. Guillain-Barre syndrome following autologous bone marrow transplantation. Am J Clin Oncol (CCT) 18(2):167-169 (1995)
• LaRussa VF, Schwazenberger MD, Miller AM, Agrawal KC, Kolls J, Weiner RS. Marrow stem cells, mesenchymal progenitor cells, and stromal progency. Cancer Invest, 20: 110-123 (2002)

See also:

• BMT clinical trials
• Research of the Tulane Bone Marrow Transplant Program, Director, Hana Safah, M.D.
  • CD34 Selected Peripheral Blood Progenitors in Partially Mismatched Allogeneic Transplant
    
  • Lipoxygenase metabolism is required for interleukin-3 dependent proliferation and cell cycle progression of the human M-07e cell line
    Alan M. Miller, Ph.D., M.D., Beverly Steel Allen, Vincent Ziboh
    
  • Metallothionine gene expression in hematopoietic progenitors"
    Krishna Agrawal, Ph.D.
  • "The role of bone marrow transplantation in the management of advanced local disease"
    from the series "Management Strategies for the Care of Advanced Primary and Metastatic Breast Cancer"
    Safah H and Weiner RS
  • "Utility of a novel modulator of gene expression in hematopoietic progenitors"
    Laura Levy, Ph.D.

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Breast Cancer

• Zakris EL, Kuske RR. Selected topics in breast cancer: local recurrence after breast conserving therapy. Prob Gen Surg 13(1): 119-128 (1996)
• Abdel-Mageed AB, Agrawal KC. Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells. Cancer Gene Ther 4(3): 199-207 (1997)
• Eck M, Yuan L, Duffy L, Ram PT, Ayettey S, Chen LL, Cohn CS, Reed JC, Hill SM. A sequential regimen of melatonin and all-trans retinoic acid induces apoptosis in human breast tumor cells. Br J Cancer 77: 2129-2137 (1998)
• Burow ME, Weldon CB, Tang Y, Navar GL, Krajewski S, Reed JC, Hammond TG, Clejan S, Beckman BS. Differences in susceptibility to tumor necrosis factor-induced apoptosis among MCF-7 breast cancer cell variants. Cancer Res 58: 4940-4946 (1998)
• Miller AM, Khosla P, Lynch J, Moreb J, Cullins S, Safah-Hutcheson C, LaRussa V, Vellis K, Rice J, Mendenhall N, Weiner RS. Durable remission of locally advanced breast cancer with multimodality management. Med Oncol 15: 89-95 (1998)
• Ram PT, Kiefer T, Silverman M, Song Y, Brown GM, Hill SM. Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth fractors. Mol Cell Endocrinol 141: 53-64 (1998)
• Hill SM, Teplitzky S, Ram PT, Kiefer T, Blask DE, Spriggs LL, Eck KE. Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. Adv Exp Med Biol 460: 345-62 (1999)
• Irminger-Finger I, Siegel B, Leung W-C. The functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and its Associated Proteins. Biol Chem 380: 117-128 (1999)
• Burow ME, Weldon CB, Chiang T-C, Tang Y, Collins-Burow BM, Rolfe K, Li S, McLachlan JA, Beckman BS. Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. Int J Oncol 16: 1179-1187 (2000)
• David O, Gattuso P, Moroz K, Dhurandhar N. Unusual cases of metastases to breast diagnosed by fine needle aspiration biopsy. Acta Cytologica (accepted) (2001)
• Dai J, Kiefer T, Yuan L, Hill SM. Retinoid orpahn receptor-alpha expression in human breast cancer and modulation of their transcriptional activity by the pineal hormone melatonin. Mol Cell Endorinol (in press) (2001)

See also:

• Breast cancer clinical trials at Tulane
• Overview of women's cancer programs at Tulane
• Women's cancers awareness scarf to promote women's cancers awareness and support research on women's cancers.

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Gastro-Intestinal Cancer

• David O, Gattuso P, Kluskens L, Reddy V. Cutaneous and subcutaneous abdominal wall lesions: a fine needle aspiration study. Diagn Cytopath 19(4): 267-9 (1998)
• David O, Green L, Reddy V, Kluskens L, Bitterman P, Attal S, Prinz R, Gattuso P. Pancreatic Masses: A multi-institutional study of 364 fine needle aspiration biopsies. Diagn Cytopath 19(6): 423-7 (1998)
• Burdsal CA, Ceasar JA. FGF-2 differentially alters the cell-ECM interactions of colon carcinoma cells which vary in metastatic potential. Mol Biol Cell 9, 431a (1998)
• David O Jakate S. Multifocal granular cell tumor of the esophagus and proximal stomach with infiltrative pattern. Arch Path and Lab Med 123(10): 967-73 (1999)
• Rekasi, Z., Varga JL, Schally AV, Plonowski A, Halmos G, Csernus B, Armatis P, Groot K. Antiproliferative actions of Growth Hormone-Releasing Hormone (GHRH) antagonists on MiaPaCa-2 human pancreatic cancer cells involve cAMP independent pathways. Peptides 22: 879-886 (2001)

See also:

• Gastro-intestinal cancer clinical trials

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Genetics and Gene Therapy

• Abdel-Mageed AB, Zhao F, Rider B, Agrawal KC. Erythropoietin-induced metallothionein gene expression: Role in proliferation of K562 cells. Exp Biol Med. 228:1033-1039 (2003)

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Genito-Urinary Cancer

• Prostate cancer:
  • Clejan S, O'Connor KC, Cowger NL, Cheles MK, Haque S, Primavera AC. Effects of simulated microgravity on DU 145 human prostate carcinoma cells. Biotechnol Bioeng 50: 587-597 (1996)
  • O'Connor KC, Enmon RM, Dotson RS, Primavera AC, Clejan S. Characterization of autocrine growth factors, their receptors and extracellular matrix present in three-dimensional cultures of DU 145 human prostate carcinoma cells grown in simulated microgravity. Tissue Eng 3: 161-171 (1997)
  • Comaru-Schally AM, Brannan W, Schally AV, Colcolough M, Monga M. Efficacy and safety of LH-RH antagonist Cetrorelix in the treatment of symptomatic benign prostatic hyperplasia. J Clin Endo Meta 83(11): 3826-3831 (1998)
  • O'Connor KC. Three-dimensional cultures of prostatic cells: tissue models for the development of novel anti-cancer therapies. Pharm Res 16: 486-493 (1999)
  • Human L, Davis R, Abdel-Mageed AB. Role of metallothionein in prostate cancer progression. Proc Am Assoc Cancer Res 41: 432 (2000)
  • Schally AV, Comaru-Schally AM, Plonowski A, Nagy A, Halmos G, Rekasi Z. Peptide analogs in the therapy of prostate cancer. Prostate 45: 158-166 (2000)
  • Clejan S, O'Connor KC, Rosensweig N. Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction. J Cell Mol Med 5: 60-73 (2001)
  • Enmon RM, O'Connor KC, Lacks DJ, Schwartz DK, Dotson RS. Dynamics of spheroid self-assembly in liquid-overlay cultures of DU 145 human prostate cancer cells. Biotechnol Bioeng 72: 579-591 (2001)
  • Davis R, Jia D, Cinar B, Sikka SC, Moparty K, Zhau HE, Chung LW, Agrawal KC. Functional androgen receptor confers sensitization of androgen-independent prostate cancer anticancer therapy via caspase activation. Biochem Biophys Res Commun. 309(4):937-45 (2003)
  • Davis R, Jia D, Cinar B, Sikka SC, Moparty K, Zhau HE, Chung LW, Agrawal KC. Functional androgen receptor confers sensitization of androgen-independent prostate cancer anticancer therapy via caspase activation. Biochem Biophys Res Commun. 309(4):937-45 (2003)
  • Holzbeierlein JM, Castle EP, Thrasher JB. Complications of androgen-deprivation therapy for prostate cancer. Clin Prostate Cancer Dec;2(3):147-52 (2003)
• Other genito-urinary cancers:
  • Bivalacqua TJ, Champion HC, Leugwattanakij S, Yang DY, Hyun JS, Abdel-Mageed AB, Sikka SC, Kadowitz PJ, Hellstrom WJ. Evaluation of nitric oxidide synthase and arginase in the induction of a Peyronie's-like condition in the rat. J Androl 22: 497-506 (2001)

See also:

• Tulane Department of Urology's Prostate Cancer Program
• Overview of men's cancer programs at the Tulane Cancer Center
• Prostate cancer awareness tie and lapel pin to promote prostate cancer awareness and support research in prostate cancer.

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Gynecological, obstetric, ovarian, cervical, & women's cancers
See also breast cancer, genito-urinary cancers

• Schally AV. Rational use of agonists and antagonists of leutenizing hormone-releasing hormone (LH-RH) in the treatment of hormone-sensitive neoplasms and gynecologic conditions. Adv Drug Delivery Rev 28: 157-169 (1997)
• Cheng PC, Schmutte, Cofer KF, Felix JC, Yu M, Dubeau L. Alterations in DNA methylation are early, but not initial events in ovarian tumorigenesis. British J Cancer 75: 396-402 (1997)
• Gonzalea-Barcena D, Banuelos R, Perez E, Cardenas I, Comaru-Schally AM, Schally AV, Engel J, Reismann T, Reithmuller-Winzen H. Treatment of uterine leiomyomas with LHRH antagonist Cetrotelix. Hum Reprod 12(9): 2028-2035 (1997)
• Dubeau L, Cheng PC. Molecular genetics of epithelial ovarian cancer. CME J Gynecol Oncol 4: 194-200 (1999)
• Lin MW, Michalopulos EA, Dhurandhar N, Cheng PC, Robinson W, Ashfaq R, Muller CY. Allelic loss and microsatellite alterations of chromosome 3p14.2 are more frequent in recurrent cervical dysplasia. Clin Cancer Res 6: 1410-1414 (2000)
• Chatzistamou, I., Schally AV, Varga JL, Groot K, Armatis P, Busto R, Halmos G. Antagonists of growth hormone-releasing hormone and somatostatin analog RC-160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice. J Clin Endocrinol Metab 86(5): 2144-2152 (2001)
• Li S, Chiang T-C, Davis GR, Williams RM, Wilson VP, McLachlan JA. Decreased expression of Wnt-7a mRNA is inversely associated with the expression of estrogen receptor a in human uterine leiomyoma. J Clin Endocrinol Metab 86(1): 454-457 (2001)

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Kidney (Renal) Cancer

• Zarifian A, Meleg-Smith S, O'Donovan R, Tesi RJ, Batuman V. (1999) Cyclosporine associated thrombotic microangiopathy in renal allografts. Kidney Int 55: 2457-2466.
• Ehrlich M, Jiang G, Fiala E, Dome J, Yu M, Long T, Youn B., Sohn O, Widschwendter M, Tomlinson G, Chintagumpala M, Champagne M, Parham D, Liang G, Malik K, Laird P. Hypomethylation and hypermethylation of DNA in Wilms tumors, Oncogene 21: 6694-6702 (2002).
• Ehrlich M, Hopkins N, Jiang G, Dome J, Yu M, Woods C, Tomlinson G, Chintagumpala M, Champagne M, Diller L, Parham D, Sawyer J. Satellite DNA hypomethylation in karyotyped Wilms tumors. Cancer Genet Cytogen, in press (2003).
• Meister L, Uri A, Agrons G, Scher CD. (1993) Wilms' tumor bone metastases at diagnosis. Med Ped Oncol 21: 446-450.
• Nguyen A, Jing Z, Mahoney PS, Davis R, Sikka SC, Agrawal KC, Abdel-Mageed AB. In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. Cancer Lett 160(2): 133-40 (2000)

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Liver (Hepatocellular) Cancer

• Nguyen A, Jing Z, Mahoney PS, Davis R, Sikka SC, Agrawal KC, Abdel-Mageed AB. In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. (2000) Cancer Lett 160(2): 133-40.
• Nguyen A, Jing Z, Mahoney S, Davis R, Sikka SC, Agrawal KC, Abdel-Mageed AB. In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. (2000) Cancer Lett 160: 133-140.
• Levy MF, Crippin J, Sutton S, Netto G, McCormack J, Curiel TJ, Goldstein RM, Newman JT, Gonwa TA, Klintmalm G. (2000) Liver allotransplantation after extracorporeal hepatic support with trangenic (hCD55/hCD59) porcine livers. Transplantation 69 (2): 272-280.
• Sullivan D, Dash S, Du H, Hiramatsu H, Aydin F, Koll J, Blanchard J, Baskin G, Gerber MA. (1997) Liver directed gene transfer in Non-human Primates. Human Gene Therapy 8: 1195-1206.
• Lu H, Ye MQ, Thung S, Gerber MA, Dash S. (2000) Hepatitis C virus RNA sequences in Cholangiocarcinoma. Chinese J Medicine 113: 1138-1141.
• Myung J, Kalkeri G, Garry RF, Dash S. (2001) Replication and assembly of Hepatitis C virus from a full-length cDNA clone pMO9.6-T7 using an adenovirus that expresses T7 RNA polymerase. J Virological Methods (in press).
• Lu H, Sullivan D, Dash S, Gerber MA. (2001) Adenovirus induced acute hepatitis in non-human primates after liver-directed gene therapy. Chinese J Medicine (in press).

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Leukemia

• Sun B, Jiang G, Zaydin M, LaRussa V, Safah H, Ehrlich M. ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. Cancer Res 61: 6931-6937 (2001).
• Hemenway CS, de Erkenezand AC, Gould GCD. (2001) The Polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. Oncogene 20:3798-3805, 2001.
• Krause JRKrause JR (2000) Morphology and classification of acute myeloid leukemias. Clin Lab Med 20: 1-16.
• Belasco JB, Luery N, Scher CD. (1990) Multiagent chemotherapy in relapsed acute lymphoblastic leukemia in children. Cancer 66: 2492-2497.
• Leahey AM, Bunin NJ, Belasco JB, Meek R, Scher CD, Lange BJ. (2000) Novel multiagent chemotherapy for bone marrow relapse of pediatric acute lymphoblastic leukemia. Med Ped Oncol 34: 313-318.

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Lung Cancer

• Liu J-Y, Morris GF, Lei W-H, Hart CE, Lasky JA, Brody AR. (1997) Rapid activation of PDGF-A and -B expression at sites of lung injury in asbestos-exposed rats. Am J Respir Cell Mol Biol 17: 129-140.
• Warshamana GS, Martinez S, Lasky JA, Corti M, Brody AR. (1998) Dexamethasone activates expression of the PDGF-alpha receptor gene and induces lung fibroblast proliferation. Am J Physiol Lung Cell Mol Physiol 274: 499-507.
• Lasky JA, Tonthat B, Liu J-Y, Friedman M, Brody AR. (1998) Up-regulation of the PDGF-alpha-receptor precedes asbestos-induced lung fibrosis in rats. Am J Respir Crit Care Med 157: 1652-1657.
• Liu J-Y, Brass DM, Hoyle GW, and Brody AR. (1998) TNF-Alpha receptor knockout mice are protected from teh fibroproliferative efects of inhaled asbestos fibers. Am J Pathol 153: 1839-1847.
• Hoyle GW, Li J, Finkelstein JB, Eisenberg T, Liu J-Y, Lasky JA, Anthas G, Morris GF, Brody AR. (1999) Empysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. Am J Pathol 154: 1763-1775.
• Brass D, Hoyle GW, Poovey HG, Liu J-Y, Brody AR. (1999) Reduced TNF-Alpha and TGF-Beta 1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure. Am J Pathol 154: 853-862.
• Weber HC, Walters J, Leyton J, Casibang M, Purdom S, Jensen RT, Coy DH, Ellis C, Clark G, Moody TW. (2001) A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. Eur J Pharmacol 412: 13-20.
• Rubio E, Chang E, David O, Kovitz KL. (2001) Pulmonary osteosarcoma: endoscopic management. J Bronchology (accepted).

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Lymphoma and Hodgkin's Disease

• Ward HA, Russo GG, McBurney EI, Millikan LE, Boh EE. (2001) Post-Transplant Primary Cutaneous T-Cell Lymphoma: A Case Presentation and Review of the Literature. J Amer Acad Derm 44: 675-680.
• Karavattathayyil S, Kalkeri G, Gaglio P, Garry RF, Krause J, Dash J, Dash S. (2000) Detection of hepatitis C virus RNA sequences in B-cell non-Hodgkin lymphoma. Am J Clin Path 113: 391-398.
• Karavattahayyl S, Gaglio P, Garry RF, Krause JR, Dash S. (2000) Detecting of hepatitis C virus sequence in B-cell non-Hodgkin's lymphoma. Am J Clin Pathol 113: 391-398.
• Habis A, Baskin GB, Murphey-Corb M, Levy LS. 1999. Simian AIDS-associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin's lymphoma. AIDS Res Human Retroviruses 15: 1389-1398.
• Habis A, Baskin GB, Simpson L, Fortgang I, Murphey-Corb M, Levy LS. 2000. Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. AIDS Res Human Retroviruses 16: 163-171.
• Fortgang I, Rege T, Baskin GB, Murphey-Corb M, Levy LS. 2001. Variation in simian immunodeficiency virus env V1 region in SAIDS-associated lymphoma. AIDS Res Human Retroviruses 17:459-465.

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Myeloma

• Batuman V, Verroust PJ, Navar GL, Kaysen JH, Goda FO, Simon E, Pontillon F, Lyles M, Bruno J, Hammond TG. (1998) Myeloma light chains are ligands for cubilin (gp280). Am J Physiol (Renal Physiol 44): F246-F254.

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Ophthalmic Cancer

• Karcioglu ZA, Toth J. (2000) Relation between p53 over-expression and clinical behavior of ocular/orbital invasion of conjunctival squamous cell carcinoma. Ophthalmic Plast Reconst Surg 16: 443-449.
• Mahmood AM, Al-Rajhi A, Riley F, Karcioglu ZA. (2001) Sclerokeratitis: An unusual presentation of squamous cell carcinoma of the conjunctiva. Ophthalmology 108: 553-558.

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This list is a representative sampling of the projects and publications of the cancer researchers at Tulane. Only a small fraction of our cancer research is cited here. To further inquire about cancer research or treatment programs at Tulane, please call one of these toll-free numbers:
1 (800) 588-5300 (Physicians) 24 hours a day
1 (800) 588-5800 (Patients and others) 8:00 am to 8:00 pm US Central Time

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Tulane Cancer Center, Box SL-68
1430 Tulane Avenue
New Orleans, Louisiana 70112-2699
(504) 988-6060, fax (504) 988-6077
http://www.som.tulane.edu/cancer