Zongbing You, M.D., Ph.D.
Assistant Professor of Structural and Cellular Biology
TCC Program Member
zyou@tulane.edu
(504) 988-0467, (504) 988-1687 fax
1430 Tulane Ave., Box SL-49, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. You received his M.D. from the West China University of Medical Sciences in 1989. He conducted his doctoral studies on the chemotherapy of gynecologic cancer under the tutelage of Dr. Zeyi Cao at the same institution, obtaining his Ph.D. in 1994. From 1994 to 1998, Dr. You was a postdoctoral fellow and then a faculty member at the Beijing Medical University, working on the molecular biology of gynecologic cancer. In 1998, Dr. You joined the University of Freiburg, Freiburg, Germany, as a research scientist to investigate adenovirus-mediated cancer gene therapy. In 2000, he moved to the University of Michigan, Ann Arbor, as a research fellow focusing on molecular signaling and apoptosis in cancer. In 2003, Dr. You joined the faculty of the University of California Davis as an adjunct instructor and then an adjunct assistant professor in the Department of Orthopaedic Surgery, working on the interleukin-17 receptor-like molecule (IL-17RL or IL-17RC) in prostate cancer. In 2008, Dr. You joined the faculty of the Tulane University Health Sciences Center as an assistant professor in the Department of Structural and Cellular Biology. Dr. You's current research focuses on the roles of the interleukin-17 family (cytokines and their receptors, particularly IL-17RC) and their molecular signaling pathways in prostate cancer oncogenesis and progression, and the development of androgen-independence. He is also initiating research programs on inflammation and stem cells in prostate cancer. The long-term goals of his research are to provide new methods in the prevention, diagnosis and treatment of prostate cancer.

Recent Publications:

• You Z, Dong Y, Kong X, Zhang Y, Vessella RL, Melamed J. Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancer. Neoplasia, 9(6), 464-470, 2007.
• You Z, Shi XB, DuRaine G, Haudenschild D, Tepper CG, Lo SH, Gandour-Edwards R, deVere White RW, Reddi AH. Interleukin-17 receptor-like gene is a novel anti-apoptotic gene highly expressed in androgen independent prostate cancer. Cancer Res, 66(1): 175-83, 2006.
• Haudenschild DR, Palmer SM, Moseley TA, You Z, Reddi AH. Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer. Cancer Res, 64:8276-8284, 2004.
• You Z, Madrid LV, Saims D, Sedivy J, Wang CY. C-Myc sensitizes cells to TNF-mediated apoptosis by inhibiting NF-kappa B transactivation. The Journal of Biological Chemistry, 277(39): 36671-36677, 2002.
• Zeng Q, Chen S, You Z, Yang F, Carey TE, Saims D, Wang CY. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NF-kappa B. The Journal of Biological Chemistry, 277(28): 25203-25208, 2002.
• You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan K, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt-1 signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of Cell Biology, 157(3): 429-440, 2002.
• Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, Kitajewski J, Wang CY. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. The Journal of Cell Biology, 152(1): 87-96, 2001.
• You Z, Ouyang H, Lopatin D, Polver PJ, Wang CY. Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity. The Journal of Biological Chemistry, 276(28): 26398-26404, 2001.
• You Z, Fischer DC, Tong X, Hasenburg A, Aguilar-Cordova E, Keiback DG. Coxsackievirus-adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression. Cancer Gene Therapy, 8(3), 168-175, 2001.
• Cao Z, You Z, Zhou S, Peng Z, Wang J, Li P. Chemotherapy for lymphatic metastatic gynecologic cancer via pelvic retroperitoneal cannulation - a preliminary report. Gynecologic Oncology, 63(3): 358-363, 1996.

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